Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 39 5 2017 12 05 Antinociceptive effect of heracleum persicum Leaf hydroethanolic extract in diabetic male mice 57 64 EN Tayebeh Moharerizadeh Naser Mirazi Journal Article 2017 10 11 Background: Pain is a protective sense in tissue injury time. Diabetes mellitus accompanies with undesirable neuropathic side-effects in long term. The aim of this study was to examine analgesic effects of hydroethanolic HeracleumPersicumL. leaf’s extract (HHE) in diabetic and intact male mice. Methods: 96 male mice were divided into 9 groups: control, treated by morphine, treated by HHE (100,200 and 400mg/kg,i.p.) , naloxone + HHE(200mg/kg) and STZ (60mg/kg, i.p) and STZ+ HHE(400mg/kg) randomly. To assess the antinociceptive effects of HHE, the animals were examined by tail-flick and writhing tests. Results: 200 and 400 mg/kg of HHE increased pain threshold compared with control group in writhing and till flick tests (p<0.001). Also the effect of administration of 400 mg/kg HHE was moreanalgesic that of morphine alone (p<0.001). Diabetic group had low threshold to pain compared to control group. Conclusion: HHE has antinociceptive and anti-diabetic effects. We suggest the analgesic effects of HHE may be due to opioid system and also it effect on prostaglandins synthesis.