Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 40 2 2018 06 05 The effect of eight -week aerobic exercise and consumption of curcumin on il-6, il-10 and BDNF in 60-65 years women with metabolic syndrome 7 14 EN Ali Osali Journal Article 2016 11 26 Background: Metabolic syndromes, pro-inflammatory and aging are main important factors in BDNF's levels. The aim of this research was to investigate the effect of eight-week aerobic exercise with moderate intensity and consumption of curcumin on IL-6, IL-10 and BDNF in 60-65 years old women with syndrome metabolic. Methods: 44 women with metabolic syndrome (MetS) voluntarily took part in the present study. Participants were randomly divided in 4 groups of MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS Curcumin (MCU), MetS control (MC). During the first week MECU group and ME participated in three sets of ten-minute aerobic exercise training (AT) with treadmill also they have 5 minute rest part between the sets. One minute was added to the duration of exercise sets weekly basis. Blood samples were conducted before and after eight -week. IL-6, IL-10 and BDNF were measured by ELISA method. To analyze the data, researcher made use of One-Way ANOVA, paired-sample t-test with the significance level of (P≤0.05). Results: IL-10, BDNF after eight -week interventions significantly increased (P≤0.05) also IL-6 levels significantly decreased (P≤0.05). Conclusion: These findings indicate eight -week interventions induce to increase BDNF's levels so maybe this increasing relative to rising in IL-10 level and decreasing in IL-6 level.