Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 40 4 2018 10 04 The Effects of aerobic training on Apelinergic system of heart tissue in aged rats 53 59 EN Parvin Farzanegi Masoumeh Habibian Mirabdollah Tahramuzi Maryam Keshvari Journal Article 2018 09 23 Background: The aim of this study was to determine the Effects of aerobic training on Apelinergic system of heart tissue in aged rats. Methods: In this study 14 elderly wistar rats with average age of 40-50 months old, were randomly divided into two groups: control and training. Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. All rats were sacrificed 48 hours after the final training session and after 24 hours of fasting myocardial tissue, apelin and its receptor levels were determined using ELISA method. Results: No significant difference was found between control and experimental group apelin heart muscle tissue there (p=0.01). Also, the apelin receptor test for heart tissue between the two groups was significant (p=0.02). Pearson correlation analysis between apelin and its receptor in the control group was statistically significant inverse linear (p=0.01), But the test for the exercise group showed no significant relationship (p= 0.44). Conclusion: It is possible that aerobic training in older people with varying levels of apelin and its receptors in heart muscle tissue, improves the cardiovascular system of the people.