Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 40 5 2018 12 05 The Effect of Eight -Week Aerobic Exercise and consumption of curcumin on IL1β and depression in 60-65 Years Old Women with Syndrome Metabolic 23 30 EN Ali Osali https://orcid.org/0000-0002-9646-4605 Journal Article 2016 11 15 Background: Metabolic syndrome and aging are main important factors in being depress. The aim of this research was to investigate the effect of eight -week aerobic exercise with moderate intensity and consumption of curcumin on IL1β and depression in 60-65 years old women with metabolic syndrome. Methods: a total of 44 women with metabolic syndrome (MetS) voluntarily took part in the present study. Participants were randomly divided in 4 groups of MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS Curcumin (MCU), MetS control (MC). During the first week MECU group and ME participated in three sets of ten-minute aerobic exercise training (AT) with treadmill (AT) also they have 5 minute rest part between the sets. One minute was added to the duration of exercise sets weekly basis. Beck depression questionnaire and blood samples were conducted before and after eight -week. IL1β was measured by ELISA method and memory test were conduct with Picture recall test. To analyze the data, researcher made use of One-Way ANOVA, paired-sample t-test with the significance level of (P≤0.05). Results: IL1β and depression significantly decreased in three experimental groups (P≤0.05) as effects of tow-month aerobic exercise. Also there was significant change in blood pressure, waist circumferences, fat percentage, triglyceride and HDL (P≤0.05). Conclusion: These findings indicated that eight -week aerobic exercise leaded to a decrease in depression and amelioration in metabolic syndrome. It is also probable that depression decrease as an effect of tow-month aerobic exercise relate with IL1β decrease.