Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 42 6 2021 02 24 The survey of clinical manifestations of infants with cow’s milk allergy according to the COMISS questionnaire 659 666 10.34172/mj.2021.006 EN Mahnaz Sadeghi Shabestari https://orcid.org/0000-0001-5356-3163 Parisa Siahsangi https://orcid.org/0000-0003-1107-6548 Mandana Rafeey https://orcid.org/0000-0001-7312-466X Maryam Hosseinpour Sarmadi https://orcid.org/0000-0002-2599-4553 Parinaz Habibi https://orcid.org/0000-0002-9052-4814 Journal Article 10.34172/mj.2021.006 2020 02 14 Background: Cow’s milk is one of the first foods added to infants’ diet and cow’s milk allergy (CMA) is the most common food allergy in the first year of life. The aim of this study was to survey the frequency of infants with cow’s milk allergy using COMISS questionnaire. Methods: In a cross-sectional, descriptive study, 100 infants were selected by a convenient method. Demographic information and clinical manifestations were completed based on COMISS Questionnaire for all infants. Data were analyzed using chi-square and independent t-test. Results: The finding of this study shows that from 100 infants (51 males, 49 females), with a mean age of 3.5 ± 1.4, 61% of them were breastfed, 30% were fed both cow’s milk and breast milk, and 9% were fed only cow’s milk. The probability of cow’s milk allergy using the COMISS Questionnaire was positive in 8% of infants. According to the criteria of this Questionnaire, 65% of infants acquired a score of 0-5, 27% scored 6-11, and 8% scored 12 and above A significant association was found between cow’s milk allergy and infant’s diet (p <0.001). A significant association was also found between growth index (weight p=0.05, height p=0.02, and head circumstance p=0.03) and CMA. Conclusion: It seems that using non-invasive methods such as COMISS Questionnaire can be helpful for the diagnosis of CMA and also breastfeeding might be reducing the allergy to cow’s milk.