Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 41 5 2019 12 01 Comparing the effects of home-based exercise rehabilitation and center based Cardiac rehabilitation on Liver Enzymes of the patients with coronary Artery disease 106 114 10.34172/mj.2019.064 EN Azam Moosavi-Sohroforouzani https://orcid.org/0000-0003-3528-0244 Fahimeh Esfarjani https://orcid.org/0000-0001-8132-8419 Farzaneh Zeynali https://orcid.org/0000-0001-7500-512X Journal Article 10.34172/mj.2019.064 2017 08 24 Background: Liver enzymes are known markers for liver dysfunction which can be associated with the risk of heart disease. This study aimed to compare the effects of the home-based exercise rehabilitation and center-based CR on changes in liver enzymes of patients with heart failure. Methods: In a semi-experimental study, 40 patients (mean age, 59 ± 6.28 years) voluntarily were divided into 3 groups: home-based exercise rehabilitation (n=13), centre –based CR (n=15) and control (n=12). Liver enzymes (Aspartat aminotransferaz (AST), Alanine aminotransferase (ALT, alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and Creatine phosphokinase (CPK)) were measured at baseline and after 2 months of CR. Data were analyzed using analysis of covariance (ANCOVA) in P < 0.05 level. Results: For the centre –based CR group, the levels of LDH and CPK after 2 months were reduced (P<0/05), While there were no significant differences in AST, ALT and ALP levels. Levels of ALT significantly reduce in the home-based exercise rehabilitation group. Conclusion: CR may have been reduce some of the liver enzymes through increased cardiac output and insulin sensitivity and improved perfusion.