Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 31 1 2009 03 22 Effect of Soybean Methanol Extract on Learning and Spatial Memory in Ovariectomized Female Rats 75 78 EN Mohammad Reza Nasirzadeh Vahab Babapour Naser Ahmadiasl Hussein Nazemiyeh Jafar Soleymani Rad Journal Article 2009 11 05 Background and Objectives: Many studies have been suggested that element's of soy extract can improve learning and memory and delay the onset of neurological disorders such as, Alzheimer's disease. However, there are a few investigation on the effects of total soy extract. So we studied the effect of total soy extract on spatial memory. Materials & Methods: In this study 30 female rats were allocated randomly to 3 groups: 1) sham (surgery without ovariectomy, 2) ovariectomized (OVX), and 3) treatment (OVX and Soy gavage). The animals of treatment group received 60 mg/kg per day total soy extract in drinking water for six weeks. Statistical analysis was performed using one way ANOVA (Tukey) test and SPSS software. Results: The results showed that ovariectomy impaired spatial memory (P<0.05) and oral administration of total soy extract ameliorated learning and spatial memory deficits of OVX rats. Conclusion: This study indicated that ingestion of total soy extract had positive effect on spatial memory especially in OVX rat.