Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 30 2 2008 06 23 Study on Urinary Beta 2 Macroglobulin as Renal Injury Index after Percutaneus Nephrolithotripsy(PCNL) 105 109 EN KAZEMI RASHID F AMJADI M ESTAKHRI R AMIRI F Journal Article 2009 12 02 Background and objectives: Percutaneous nephrolithotripsy in selected cases represents the method of choice in treatment of urinary stones. The results of that are excellent and stone free rate is more than 90% but the sideeffects on kidney had less studied. To evaluate renal injury relative this procedure preoperative and post operative urinary levels of Beta 2 macroglobulin, a sensitive markers of renal tubular damage were studied. Materials and methods: Urine samples of 20 patients who were treated for renal stones by PCNL were collected before and after 24 hours, 3 days, 7 days and 14 days in both for measuring beta 2 microglobulin. The increase and decrease of beta 2 microglobulin and its relation with stone size and duration of lithotripsy have been analyzed. Also 20 patients after varicocelectomy were included in this study as control group. Result: PCNL and varicocelectomy were done without special complication. There was significant rising of urinary beta 2 microglobulin in early period after PCNL. There wasn't relation between increasing beta 2 microglobulin and duration of surgery or size of stone (p=0.983, p=0.165). Conclusion: PCNL is an effective treatment of renal stone with a transient tubular damage. It has no permanent deterioration on renal function.