Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 34 6 2013 02 26 Comparison‍‍‍‍ of Efficacy of Topical Combination Solution of Salicylic Acid %2 and Erythromycin% 4 with Topical Solution of Erythromycin 4% Alone in Mild to Moderate Acne Vulgaris Treatment: A Double-Blinded Randomized Clinical Trial 67 71 EN Farideh Golfroushan Hamideh Azimi Ebrahim Tayefeh Hosein Ali Journal Article 2013 02 26 Background and Objectives: Acne Vulgaris is one of the most common skin disorders involving pilosebaceous units resulting in hyperkeratinization, sebum production and inflammation. It involves 85% of individuals aging 12 to 24 years a physiologic phenomenon in this age group. Materials and Methods: 50 patients with mild to moderate acne vulgaris were subdivided in two equal groups, groups and it is (group A & group B each other with 25 patients) in a double-blinded trial; the therapeutic effect of topical erythromycin solution 4% was with combination of erythromycin 4% and salicylic acid 2%. Results: In this recruitees 14 (28%) patients were male and 36 (72%) were female. The mean age of patients was 20.3±3.2 15 to 29 years. The mean TLC after treatment in erythromycin group was 21.6±6.6 while in combination therapy group it was 9.8±5 (P=0.0001). 16% of patients in erythromycin group and 76% of patients in erythromycin plus salicylic acid experienced complications including irritation, erythema and xerosis which was significantly different (P=0.0001). Conclusion: The efficacy therapy with combination of erythromycin 4% and salicylic 2% is more than erythromycin 4% alone in the treatment of facial acne vulgaris, but side effects were more prominent in combination therapy.