Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 35 5 2013 12 05 Staphylococcus Aureus Resistance to Vancomycin: A Six Years Survey, (2006-2012) 40 45 EN Sedigheh Khazaei Pegah Pourtahmaseby Malek Kanani Seyed Hamid Madani Ehsan Malekianzadeh Journal Article 2013 02 19 2013 06 16 Background and Objectives: According to the widespread prevalence of methicillin resistant Staphylococcus Aureus (SA). The glycopeptide vancomycine is the only uniformly effective therapy for infection. Importance of vancomycine antibiogram in treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) needs to be evaluated. This study investigated prevalence of S.A resistance to vancomycin. Materials and Methods: All samples which submitted for culture during 6years period (2006-2012) were selected and cultured on Mac-Conkey and Blood Agars, and differential media. After the diagnosis and isolation of Staphylococcus aureus, antibiogram profile of the bacteria was determined by disk-diffusion test (Kirby-Bauer) and interpreted according to CLSI standards. Results: Of 5736 samples of Staphylococcus, 3987 (%69.5) specimens were positive for S.A. 3897 (%68.1) strains of S.A were isolated from urine and 966(%16.9) were isolated from blood, and oters from wound, throat, sputum and etc. Antibiotic susceptibility results reveal that the prevalence was %4.8. Conclusion: The antimicrobial susceptibility test of SA may defer by geographic regions. In this study, the prevalence of vancomycin resistant strains is increasing gradually and due to importance of vancomycin antibiogram in treatment of MRSA, more attentions and studies are recommended.