Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 35 6 2014 02 05 Evaluating the Effect of One Stage Full Mouth Disinfection on Serum IL-17 and IL-23 Levels in Patients with Moderate to Severe Chronic Periodontitis 20 25 EN Parviz Torkzaban Reza Pourabbas Mehrdad Hajilooi Farnaz Jafari Ali Zarandi Journal Article 2011 04 03 2011 08 20 Backgrounds and Objectives: The main purpose of one-stage full-mouth disinfection is the rapid elimination or depletion of all oro-pharyngeal pathogens using scaling and root planning, subgingival periodontal pocket irrigation and tongue disinfection. The aim of the present study was to evaluate the effect of this technique on serum levels of IL-17 and IL-23 in patients with moderate-to-advanced chronic periodontitis. Materials and Methods: This randomized clinical trial study conducted on 24 eligible patients with moderate to advanced chronic generalized periodontitis. 20 (11 male- 9 female), healthy subjects and with no history of drug therapy during the last 6 months were included in the study. Blood samples were taken from the patients before the intervention. Then, full-mouth disinfection was carried out in one session. Blood samples were taken again 6 weeks after the intervention. The ELISA method was used to evaluate serum levels of IL-17 and IL-23. Results: The Pre and post-treatment serum levels of IL-17 were 103.8±38.6 and 14.1±8.6 pg/mL, respectively (P=0.003); in case of IL-23, The Pre and post-treatment serum levels were 124.9±40.1 and 17±8.8 pg/mL, respectively (P = 0.001). The differences were statistically significant in both cases. Conclusion: In patients with moderate-to-advanced chronic periodontitis, serum levels of IL-17 and IL-23 significantly decrease subsequent to one-stage full-mouth disinfection.