Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 36 1 2014 04 06 Effect of Aerobic Training with Omega-3 Consumption on Soluble Adhesion Molecules in the Obese Women 20 27 EN Asghar Tofighi Ghafour Ghafari Journal Article 2013 04 04 2013 05 06 Background and Objectives: Obesity is a growing cause of cardiovascular diseases. Accordingly, the aim in present study was to investigate the effect of Aerobic Training with Omega-3 Consumption on Soluble Adhesion Molecules in the Obese Women. Materials and Methods: In a double-blind study, 40 obese women (BMI ≥30) 55 to 65 years were selected, and randomly divided into 4 groups (n=10 for each group): exercise-supplementation, exercise-placebo, supplementation, and control. Subjects in the supplementation group consumed 2080 mg omega-3 daily and the placebo group consumed a 0.02 dextrose solution as a placebo. The exercise program comprised aerobic exercise to 45% to 65% maximum heart rate for 8 weeks; each session was sustained for 40 min and continued for 3 sessions per week. Results: Exercise, supplementation and combined exercise – supplement can sICAM-1 concentration significantly decreased (P< 0.05). On the other hand, serum sVCAM-1 concentration decreased significantly only in the exercise-supplement group (combined) and IL-6 concentration significantly decreased in the exercise group and exercise-supplement group (combined) (P < 0.05). Conclusions: Measurement of Adhesion Molecules is a useful method in the diagnosis of inflammation and vascular disorders. In addition, regular aerobic exercise and omega-3 supplements are two effective and moderating factors; in reducing the of adhesion molecules and pre-inflammatory cytokines.