Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 36 1 2014 04 06 Effects of Hydroethanolic Extract of Elaeagnus angustifolia on Pentylenetetrazole Induced Seizure in Male Mice 74 81 EN Naser Mirazi Abdolkarim Hosseini Journal Article 2013 04 15 2013 06 16 Background and Objectives: Epilepsy is a major cause of morbidity in patients. Elaeagnus angustifolia has antioxidant and anti-inflammatory activity. The effects of this traditional herbal medicine on Pentylenetetrazole (PTZ) -induced seizure have not been studied yet. The present study evaluated the effects of E. angustifolia on PTZ-induced seizure in male mice. Materials and Methods: 30 male mice (30±5 g) were randomly divided into 5 groups including: control, normal saline, phenobarbital and E. angustifolia’s extract group at doses 200 and 400 mg/Kg. The groups were intraperitoneally administered 3 mg/kg phenobarbital, 200 and 400 mg/kg E. angustifolia’s extract for 2 hours before PTZ injection and 1 ml/kg normal saline for one week (n=6 per group). Seizure induced by administration of PTZ (1%) solution via tail vein of mice. All data were expressed as mean±SEM. One way ANOVA used for statistical evaluation. Statistical significance was accepted at P<0.05. Results: The administration of Elaeagnus angustifolia’s extract at doses 200 and 400 mg/kg was significantly increased Seizure threshold in PTZ-induced mice compared with control group (P <0.001). Conclusion: The hydroethanolic extract of Elaeagnus angustifolia has anticonvulsant effects, possibly through an interaction with inhibitory and excitatory system, antioxidant mechanisms, and ion chennel inhibition.