Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 36 5 2014 12 07 Effect of Different Doses of Caffeine Intake on Indirect Markers of Resistance Exhausting Exercise-Induced Cellular Damage in Male Volleyball Players 54 61 EN Ali Zarghami Khameneh Afshar Jafari Ebrahim Akhtari Shojaei Journal Article 2013 09 20 2013 12 15 Background and Objectives: Caffeine is a well know substance with widely usage worldwide. Today some researches confirmed the conflicting effects of caffeine compound on cellular damage markers. The aim of this study was to determine the effect of different dosage of caffeine intake on some cellular damage markers in serum of male volleyball players after the one-single exhaustive resistance exercise. Materials and Methods: In a randomized double-blind design study, thirty elite male volleyball players (mean aged 21.47±1.45 years, fat percentage 10.47±3.11 % and BMI 23.15±1.26 kg.m2) were categorized to three equal groups: supplement groups (with 6 and 9 mg.kg-1 caffeine) and placebo group (6 mg.kg-1 dextrose). After the supplementation, all subjects were participated in one-single-session of resistance weight-training (with 80% of one repetition maximum until exhaustive). Changes in cellular damage indices (total serum CK, LDH and AST) were determined in three phases (Baseline, immediately and 24 hours after the training protocol). The normal data were analyzed by repeated measure ANOVA and Bonferroni at α≤0.05. Results: Different doses of caffeine intake had no significant effect on increased level of cellular damage serum enzymes immediately after exercise compared with the placebo group (P≥0.05). Also, exhaustive resistance exercise significantly increased levels of 24-hour CK, LDH and AST in all groups (P≤0.05). However, different doses of caffeine intake had not effect on increased levels of cell damage markers after 24 hours of exercise (P≥0.05). Conclusion: Based on the present findings, it could be concluded that acute intake of different doses of caffeine did not significantly prevent further damage؛ however it was not made the deterioration of the indirect indices of cell damage in compared with the placebo group.