Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 36 5 2014 12 07 Effect of Lippia Citriodora on Anxiety Behaviour in Adult Male Rats 68 73 EN Maryam Eidi Ali Ilchizadeh Kavgani Saleh Shahabzadeh Zahra Sasaninezhad Reza Ghahramani Mostafa Hamidi Nomani Journal Article 2013 10 22 2014 01 08 Background and Objectives: Anxiety is as a common disorder can be treated with botanical medicines. Herbal medicine and complementary and alternative medicine have widespread usage among individuals with mood and anxiety disorders. The benefit effect of Lippia citriodora is proposed for treatment of various neurological diseases. In the present study the effect of Lippia citriodora extract on anxiety behavior was evaluated in adult male rats by elevated plus maze. Materials and Methods: In experimental study, Lippia citriodora extract at doses 50, 100, 200 and 300 mg/kg was administrated in adult male rats, interperitoneally. The control group was treated saline as vehicle. 30 minutes after treatment, anxiolytic effect of plant was evaluated by elevated plus maze during 300 s. Results: Treatment of Lippia citriodora hydro-ethanolic extract at dose 200 mg/kg increased staying in open arm and ratio of open arm entries to whole arms entries (%OAE) and at doses 50, 100 and 200 mg/kg reduced ratio of time of first entry to open arm to time of first entry to whole arms (%OAT). Conclusion: Extract of Lippia citriodora leaves has anxiolytic effect in rats and the effect may be related to flavonoids and interaction with GABAergic system.