Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 36 5 2014 12 07 The effect of Epigallocatechin-3-Gallate on Spatial Memory after Demyelination Induced by Lysolecithin in Rat Hippocampus Formation 88 95 EN Najmeh Kiamarsian Shiva Khezri Minoo Ilkhanipour Journal Article 2013 10 03 2014 01 08 Background and Objectives: Multiple Sclerosis (MS) is an autoimmune disorder in central nervous system characterized by neuroinflammation. In this study, the effect of Epigallocatechin-3-Gallate (EGCG) on learning and spatial memory was investigated following a demyelination induction using lysolecithin injection into the rat hippocampus. Materials and Methods: In this experimental study, for the demyelination induction, 2µl lysolecithin (LPC) was injected streotaxically into the dentate gyros. Then, animals received 30mg/kg catechin for 7, 14, and 28 days after demyelination induced by lysolecithin. Subsequently, the spatial memory was investigated by a radial maze. Repeated measurement used for statistical evaluation. Results: The impairment of the spatial memory was more significant 7 and 14 days after the LPC injection. Hence, food finding time has increased significantly compared to the control group (P<0/001). Moreover, the administration of EGCG has improved the spatial memory so that receiving EGCG for a longer time e.g. 28 days after demyelination induction can significantly recover the learning and spatial memory compared to the LPC-receiving group (P<.001). Conclusion: The long-term administration of EGCG can improve the spatial memory and learning of rats. Hence, it can be suggested as a treatment for demyelinated disease such as MS.