Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 37 3 2015 08 05 Effect of Fe4NiO4Zn Nanoparticles on Serum Urea-Uric Acid and Creatinine in Male Rat 6 11 EN Negin Azadeh Zahra Hooshmandi Mahbubeh Setorki Journal Article 2015 02 11 2015 05 20 Background and Objectives: Regarding to the increasing of zinc oxide-iron-nickel nanoparticles and their applications in the biological systems, it seems that there are less investigations on their side effects in the organisms. In this research the effect of Fe4NiO4Zn nanoparticles on renal function was investigated. Materials and Methods: Twenty four Wistar rat were studied. They were divided into three groups: 1) control group (2,3) treated groups, These groups received. . /5cc of saline, /5cc of solution containing 100, 200 ppm Fe2NiO4 for 7 successive days, respectively. Then renal parameters such as uric acid, creatinine and BUN (blood urea nitrogen) were evaluated at (2, 7 and 14 days). Results: Mean uric acid levels, at 7 day after the intervention, were significantly increased in both doses. Also, in group 2 (Fe4NiO4Zn 100 ppm), mean uric acid, levels at 7, 14 day after the intervention were significantly increased. Mean BUN levels showed significant decrease in comparison with control group (at 2-7-14 days) in both doses. In high dose (Fe4NiO4Zn 200 ppm), mean creatinine levels showed significant decrease. Conclusion: Results of this study showed that Fe4NiO4Zn can influence the renal function. The difference in tissue distribution, penetration, and damage of nanoparticles in various studies is probably due to the difference in their synthesis method that leads to the changes in size, shape, and other physical and chemical properties of nanoparticles. It seems that the application of Fe4NiO4Zn nanoparticles in the biological system has no stable and long-term toxic effects on the animal body. Probably the reticuloendothelial system excretes the nanoparticles from the body.