Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 37 6 2016 02 05 The Effect of Buspirone Hydrochloride on Serum Insulin, Glucose and Lipids in Diabetic Adult Male Rats 12 17 EN Seyed Ebrahim Hosseini Saeed Khatamsaz Sharareh Mohagheghzadeh Journal Article 2014 01 22 2014 02 27 Background & Objectives: Buspirone is an efficient inhibitor of serotonin reabsorption and ausful medicine in the treatment of anxiety disorders and compared with benzodiazepines has less physical dependence. The purpose of the study was to evaluate the effect of buspirone on serum levels of insulin, glucose and lipids in the diabetic rats. Material and Methods: In this experimental study, 35 adult male rats were divided into 5 groups of with 7 rats in each group. Diabetes induced by injection of Streptozotocin in Experimental and sham groups. Different doses of buspirone including 5, 10 and 15mg/kg were injected to experimental groups intraperitoneally for 7 days. The animals of control and sham groups received only distilled water by phlebotomizing of animals hearts serum sample were concentrations of insulin, glucose and lipids were measured. Results were compared with sham and control groups obtained were evaluated by using the Tukey test, T, ANOVA and Duncan. Results: Statistical analysis showed that buspirone causes a significant increase in insulin in experimental recipient groups and a significant glucose reduction in the experimental group at the value of, P=0/0005 but doses not affect the plasma concentrations of lipids significantly. Conclusions: Buspirone by inhibiting the specific receptors increasing the could lead to insulin release serotonin may be caused to release the insulin. Additionaly 1-(2-Pyrimidinyl)-piperazine as active metabolite of buspirone may have some role in increasing insulin release facilitate the release of insulin, which could be led to lower glucose in blood.