Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 38 1 2016 04 05 Ghrelin Concentration Changes Response to Regular Resistance Exercise Training 50 55 EN Kamal Azizbeigi Sirvan Atashak Kawe Batoorak Journal Article 2016 04 26 Background and Objectives: According to the prevalence of obesity and its complications in Iran and worldwide, the cognition of effective methods that reduce the risk factors and implications in obese persons can have significant clinical appliances. Hence, the aim of this study was to determine the effects of 12 weeks of regular resistance exercise training on plasma levels of ghrelin in the obese men. Material and Methods: Twenty obese men (BMI≥ 30, 18-32 years)) were selected and randomly divided in to the two resistance training (n=10) and control (n=10) groups. Resistance training was performed three times a week on alternate days for 12 weeks and included 8 exercises. At baseline and after last training session, blood samples were taken in 12-14 hours fasting state from all subjects and ghrelin plasma levels before and after the protocol were measured. The paired and unpaired t-tests were used for statistical analysis P value <0.05 was significant. Results: Compared to pre-training, after 12 weeks of regular exercise training, the plasma ghrelin levels significantly increased (P<0.05) in the training group, while it remained unchanged in control subjects (P>0.05). Conclusion: The results of this study indicated that the long term exercise training significantly increases the ghrelin plasma levels. Hence, it is recommended that this type of training can be used as an effective and low-cost therapeutic method to control the body composition in the obese men.