Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 45 5 2023 12 06 Presentation of a case with fever, lymphadenopathy and thrombocytopenia: a case report 462 467 10.34172/mj.2023.048 EN Maassoumeh Akhlaghi https://orcid.org/0000-0002-4341-0486 Kiarash Kazemi https://orcid.org/0000-0002-3515-7118 Soheila Sobhani Journal Article 10.34172/mj.2023.048 2023 03 03 2023 05 03 The three primary differential diagnoses for a patient with systemic and hematological involvements (fever, lymphadenopathy, and hepatosplenomegaly), skin rashes, and sore pharynx are infections, connective tissue diseases, and malignancies. In this case report, we discuss possible illusory similarities between these categories that can aid in the diagnostic workup of primary care physicians. Practical Implications. The clinical course of (Infections mononncleosis, MI) patients with and their histopathological data rarely differ; Therefore, early testing for IM caused by EBV is recommended. This article will help physicians face similar cases